Im running 2.5 on my 3rz, 37mtr's and had bias 36's before. Have no issues on the highway. I will admit i kind of drive like an a55 and find myself speeding from time to time. Speed limit is 75 and because i still dont have my VSS in I cant be 100% sure how fast i was going but my buddy said we hit 100+ one night screwing around on the highway.
Mods
2.5 manifold back, Stock cat, borla muffler and 2 bullet mufflers
K&N intake for tacoma
5:29's
TRD Radiator cap(=1000hp i know)
Other then that bone stock motor
on the trail i have duals with a 4.7 case and i have plenty working for me. I feel like the truck lacks a slight bit down low sometimes but im in CO so im sure it doesnt run like most of you guys in CA or sea level.