I'd love to do a quality build on a 22r block, break it in right, switch to synthetic and see if I could get several hundred thousand miles out of it.
I guess I will be the guinea pig for this quote. My last 3 vehicles were new and I have switched from dino oil to synthetic in the first 1000 miles of their engines life. Note that I only put about 40k on each, but without a problem. I look to put MANY more miles than that on my truck.