Well, I own a 91 pickup, 22RE, and I love it. Of course, I'm a little biased, but in my opinion that little 4cyl gets my truck movin pretty good. I've got the stock 4.10s and like 225-75 15 tires. I can hit 85-90 mph on the freeway with still alittle left in the motor. Mileage is good, great on the highway, and reliablility is great also. Aside from the oil leak, I have had zero trouble with the motor, It has about 135000 miles. It even passed emissions tests, 2 speed idle. I'd imagine that a V6 in the same truck would be a little quicker, I'm not sure what the mileage would be like, probably not that much different. Personally I would go for the 22RE, one major factor is that from what I've seen, there seems to be more aftermarket parts for the 22RE and it's drivetrain than any of the V6 motors. The four cylinder will also be lighter in wieght which will help with weight distribution. Just remember, horsepower isn't everything...Hope this helps!
