Opioids are in great supply at least! No issue hooking the population on that. With the exception of the occasional Ibuprofen or Acetaminophen to take the edge off when it get rediculous, drugs are not a factor in my life. So the lack thereof is not a concern. As for those hokked on "necessary" prescription drugs? There are natural alternatives for most of the man made chemicals that mimic the nature. Y'know, since natural compounds cannot be patented drug companies cannot claim them as their own and not make huge profit on them. Yep, like most everything they offer is a close copy of something found in nature.
Depression and manic episodes? I'm bi-polar anyway, wouldn't notice any extra depression or manic episodes. I prefer the depression over the manic episodes. It's a lot cheaper and safer hiding in a dark room than getting out and going nuts.