Good point on the toxicity levels. Definately pay attention to anything you consume. Even SOME of the most toxic substances we know of can be beneficial in small doses, Arsenic, Strychnine, Amygdalin etc.. I've told people in the past that Arsenic, when used properly, is like lubricant for the nervous system. It is a very thin line though.
Also need to pay attention to chemicals that can build up in your system, like metals.
Some beneficial foods need to be consumed at intevals, like "Velvet Beans", which are high in dopamine. And the afore mentioned Tribulus Terrestris. Not so much as having addictive properties, but can alter the body's way of utilizing chemicals.
So yeah, do your homework.