Funny how a stock to mild build 22R/E can last almost forever, Up to 50% increase can be almost as reliable. Playing with the rod/stroke ratio can improve the reliablity with hogher output engines. Then Toyota slapped a turbo on it. I think they were a bit hasty in that move. Problems I found with the 22R-TE include an inadequate exhaust system, and they used the 22R intake ports, not to mention the camshaft and ECU tuning.
Best thing to do with a 22R-TE is a higher compression with low boost, instead of increasing boost pressure. That would take advantage of the "dogleg" design swirl-port. Higher boost gets restricted with that port design, needs a reengineered port. Get rid of the dogleg and straighten the port, or just adapt a 20R head.
A freer flowing exhaust would have alleviated some of the issues with the turbo and manifold.
The cam allowed too much backflow against the intake. The ECU tuning was not well defined and sensors were a bit weak.
Toyota would have been better off superchaargung the 22RE.
But that's just me.
A $5,000 budget can build a 22RE that can make a hardcore "gotta keep my 22R" person happy. Do need the basic "intended use" info to start though. For the sake of torque I'd put the first $1500 into increasing the stroke.