I was running a buick 4.1 engine 200+ hp with 4:88's and 33's behind a g52 transmission for a while and it sucked as far as drivability way too much gear and terrible gas mileage but I never liked the 4 cyl with the 4:88's with 33's it was too much gear. and I got about the same mileage. I now have 4:56 gears and a r150f v6 tranny and 35's and dual cases it should be a lot more streetable with the torque of the v6 since it is set up for low end to mid range torque rather than top end hp.
with the 4:88's and 33's I was just winding everywhere I went and 55 with in 5th the engine was running in the 35-3600 rpm range to go 65 it was really winding. I went to 35's and that helped a little but I still didn't like it.
it felt like a drag car with low gears with the old set up.
so the gearing will make a big difference and it may be worth it for the mileage differences to have the extra power
have you looked into the 5 mg and 7 mg engine swaps they offer about the same gas mileage with lots more power
but more power usually means more breakage too.
I like the super charger idea too and the extra injector too get ya 300 hp. just watch out for the transmission at that level.