yea you'll have rubage, kinda depends on the size tire and lift though not just the width.
I HAD 37x12.50's on an 82' with 8" lift and it rubbed the outer frame rails in the back (lightly) and the front rubbed the inner kick panels on the cab pretty bad.
I've since got 2" spacers f/r and cut back the front a little and its not so bad.