well, looking around on pirate, i saw a comparison between factory 4.88s and a normal v6 third with 4.88s. the factory setup looks stronger -- the ring gear on the normal v6 third is THICK! which makes the pinion a lot smaller.
however, the more important thing in the picture was that the factory setup had a spool installed! so i'm guessing it is possible. the nice thing about the V6 3rd is that lockrites are cheap! $198!