Hell Yea! Might be a little to big though.

no such thing as too big    honestly though, i doubt you will have any problems having too much power for those axles with a big block. I dont think you wil be breaking axle parts even when you get on the skinny in a sketchy situation.

To answer your question, I think a 22RE would be fine with those gears and dual cases, however you might want to tow it places to wheel because you wont be goin to fast on the road with that running gear.