I did the straight through trip once in the 4Runner which made it a longer trip than your 16+ hour trip, but had a 2nd driver which made it easier for sure. I was ready to be done driving at the top of the pass on that trip...
I did the straight shot from Moab to AZ trip home when I was there and the 8 hours was killer for me, driving by myself! I don't know that I could do 16 hours straight any more.
Gnarls.