One thing I might note with regards to tuning the 22RE. They are always pretty weak, in my mind. So, one quickly becomes used to the mods that were done and the truck gets back to feeling slow. All I have to do when that happens is hop in one of my friend's toys to remind myself that I have the fastest 22re amongst them.
I don't really know enough about tuning, but there is some sort of range available from the ecu. It is EFI after all, it does look at the mixture and adjust accordingly. So it stands to reason if I can increase flow I will get more power, within the limits of the fuel map and the injectors. Currently I am happy with the OS valves and open exhaust and I will never take that any further.
As for WOT, in this motor that is open loop, correct? So, with too much flow we are going to lean out the motor, possibly dangerously. If one could edit that WOT mapping maybe we could get somewhere.
Personally I nearly always stay out of WOT on these motors, they actually seem to have a bit more power when you are close to WOT but not all the way there.