I would imagine the difference in 1st and 2nd is pretty similar to swapping out your 29's or 30's for 33's with stock gears...
No way. Huge difference. My buddy has 37 inch tires on his stock-geared rig and still burns rubber on pavement.
2nd gear, even without those tires - would not leave rubber. No way.
Add to that starting uphill, and you double the damage.