yes.
you will need to modify the e-brake cable. if possible, grab the one off the truck you got the axle from. (that's the easiest.)
Oh, depending, the pumpkin flnage will have a different hole pattern, so redrill flange.
If junk yard axle, or one sitting, be prepared to rebuild the damn thing. (another ~150 depending)
While you have the new one out, SHAVE the drain plug off. If you visit rocks frequently, you will be glad you did!!!