Depends on what you think really. Its hard for us to say, without knowing the vehicle. I wouldn't try to drive my truck to North Pole, AK and its got about 220K on it, (3rd gen toy) but I also know a guy who has an '84 2wd that has something liek 600k on the original motor that I would drive that thing to China if I had to.
It really comes down to what you think, are comfortable with, and your experience with the truck. Regardless of what you decide,
"Hope for the best, prepare for the worst"