I'm in the same boat, Looking for a header that will fit my 1980 pickup 4x4 with a newer 22r. LCE told me their header will not fit due to the frame rails being narrower. I'm sure there's plenty of people with this combo running headers on a first get 4x4 with newer engine block.
I have a LCE header on the 22re in my 1980. I had to take the heat shield off the frame, then it fit fine