I had great luck with the 270 I ran in my 22RTE.  The engine was bored to 93mm, massaged head w/ HD valve springs, rebuilt rockers, '82 Supra VAFM, 440cc injectors, '89 Supra intercooler and 3" turbo back exhaust.  From 2500 to 5500 it pulled real hard!  My buddy ran a 260 in his stock 22RE and it was fine.  He picked up a gear's performance on the highway and "claims" he's getting better mileage.