As long as you are reasonable w/the boost no issues w/reliability. Most of the "boom" stories come from newbies who buy a used one, then crank up the boost w/o any idea of the state of the engine, then comp;lain when an HG goes.
Here's the thing about all this Wow-Power... first, in the video, Duane admittedly went through 5 turbos and 2 engines. Just an estimate of round numbers of cash, not including all other cost of time, @ $3K per turbo and 2 engines, he's probably spent $15,000 just for turbos alone. On his 2nd engine... another 10 grand... he most likely spent north of $30,000.
Now about "one-time" dyno tests on wow-power engines... we can dyno test Duane's machine once... all good... happy numbers! How many hours before that engine goes BOOM? Can we dyno test that same machine 3 months later, 6 months later, 1 year later? I'd willing wager a bet that I can dyno my new engine (when I get it in my truck and broken in), then 1 year later and 3 years later, and 5 years later, it will still show the same or very nearly the same numbers on the same Mustang chassis dyno.
Mosk (Mr. 22RE Turbo) went through at least 3 turbos and a couple engines. Unless you are a NASCAR team or a NHRA team with multi-million dollars contributed by sponsors, with the best engine builders on the planet, with access to the most advanced automotive parts anywhere, can YOU afford to blow up a $30K engine, or $5K engine?
Is the discussion about how much power you can get out of 22 engine and keep it reliable, drivable, and within some reasonable expenditure to the average DIYer?
To me it boils down to INCREASE = LESS RELIABILITY. If you take a stock 22R at 100 HP that's good for 100,000 miles. If you take a stock 22R and slap a $3,000 blower on it you get 50% increase or 150 HP... and now your reliability goes down by 50%... so will it be reliable for 100,000 miles... probably not.
A 358 cubic inch naturally aspirated NASCAR engine takes over 100 hours to build, designed to live at 9,000 RPM for hours, producing about 800 HP - for ONE race. The cost is around $80,000.
If a top fuel nitro-buring dragster with a 500 cu engine producing about 10,000 HP can make one pass with no failures, it costs about $15,000. The engines are opened after every run.
Gnarls.