I'm not an expert on these engines but I've built a few engines in my time and the 22R bottom end looks plenty beefy to me for anything short of a full race buildup. Forged crank, forged rods, 5 main caps, fully skirted block = stout. If you're really concerned about it, get an ARP main stud kit but I can't really see that being necessary for anything you'll be driving on the street. If you do get the main stud kit keep in mind you'll have to have the main bore honed in the block, which will shorten the distance between crankshaft and camshaft centerlines slightly.
I'd focus more on the head/valvetrain - that's where the power is and where your most likely point of failure is as well.
