I have an 85 22R with a Weber Carb.  I only run premium (92) fuel

I had an 84 22r with a weber, cam, header and exhaust.  I set the timing at stock and ran mid grade fuel.  On a side note, that thing was a fuel miser when you weren't looking, but as soon as you looked at the gauge it would go down.  Really.  No, my commute went uphill alot, and as soon as I came downhill into town bye bye sweet gas mileage.  It was prety good around town though for the setup.