Depends on what's in front of, I would say. Small block Chevy, no. Stock 20R, sure. I have my stock, 228K mile, G52 behind a 3RZ and haven't had any trouble in 25K miles since the swap was complete a few months ago.
33" tires, stock 4.10 gears for now. I have V6 4.88 thirds & a W56B trans if they fail though... But figured I'd wait til 35s come....